Diagnostic impact of echo planar diffusion-weighted magnetic resonance imaging (DWI) in musculoskeletal neoplastic masses using apparent diffusion coefficient (ADC) mapping as a quantitative assessment tool

摘要

Purpose To evaluate the diagnostic impact of echo planar DW imaging in distinguishing benign from malignant musculoskeletal soft-tissue masses using ADC mapping as a quantitative assessment tool. Patients and methods We evaluated 73 tumors (21 bone tumors and 52 soft-tissue tumors). MR examinations were performed with a 1.5-T system. Diffusion-weighted single-shot EPI images were obtained in all patients. Apparent diffusion coefficients (ADCs) were calculated by using b factors of 0 and 1000 s/mm 2 . ADC value measurements were compared with the histopathological findings. Results The average ADC of benign tumors was 1.86 ± 0.67 × 10 ?3 mm 2 /s, and that of malignant soft-tissue tumors was 0.97 ± 0.35 × 10 ?3 mm 2 /s. ADC value of malignant tumors was significantly lower than that of the benign tumor group ( p 0.0001). The highest ADC value was seen in the case of ganglion cyst (2.8 ± 0.23 × 10 ?3 mm 2 /s) and cystic neurofibroma (2.5 ± 0.04 × 10 ?3 mm 2 /s), and juxta cortical enchondroma (2.65 ± 0.36 × 10 ?3 mm 2 /s) while the lowest one was seen in aggressive fibromatosis (0.37 ± 0.05 × 10 ?3 mm 2 /s). For malignant soft-tissue masses, the highest ADC value was seen in mesenchymal chondrosarcoma (2.1 ± 0.32) liposarcoma (intermediate grade) (1.4 ± 0.21) while the lowest ADC value was seen in fibrosarcoma (high grade) (0.78 ± 0.14). Conclusion MR diffusion provides additional information to the routine MRI sequences rendering it an effective non-invasive tool in differentiating between benign and malignant soft-tissue tumors.