Pentoxifylline As A Radioprotector Against Certain Biochemical And Metal Disorders Of Whole Body Gamma Irradiation In Rats

摘要

Introduction :- The effect of whole body gamma irradiation at 6.5 Gy dose level on some biochemical indices and metal levels has been investigated in albino rats. Material And Method:- These included the determination of lipid peroxidation and metallothionein (MT) in liver and kidney. Iron, copper and zinc were measured in liver, kidney spleen and intestine. Also the P50 of survival was determined in rats. Results:- For the control of these radiation-induced disorders, the radioprotective character of pentoxifylline has been evaluated. Acute -radiation-induced disturbances in trace metals levels in some organs were studied; specially Fe concentrations which were significantly increased (p0.05) in liver, spleen and intestine. Also -radiation-induced increase in malonaldehyde (MDA) levels as lipid peroxidation indicator and decrease metallothionein (MT)-induction as antioxidant defense induced in the cell. Pre-treatment with pentoxifylline was not effective against the changes produced by acute -radiation on metals studied, lipid peroxidation process and MT-induction. While post treatment showed positive effect on liver iron and metallothionein levels in liver and kidney.