Autoimmune thyroid disease in Egyptian patients with rheumatoid arthritis

摘要

Aim of the workTo determine the frequency of autoimmune thyroid disease (AITD), anti-thyroglobulin (ATG) and anti-thyroid peroxidase (ATPO) antibodies in Egyptian patients with rheumatoid arthritis (RA).Patients and methods60 RA patients and 60 matched controls were enrolled. Clinical and laboratory data were examined in the patients. The disease activity score (DAS28) and modified health assessment questionnaire (MHAQ) were evaluated. Presence of AITD, ATG and ATPO antibodies were assessed.ResultsThe mean age of the patients was 41?±?10.5?years, 43 (71.7%) were females and had a disease duration of 8.6?±?4.1?years. Their mean anti-cyclic citrullinated peptide level was 31.8?±?33.5?IU/ml), DAS28 (4?±?1.4) and MHAQ was 1.5?±?0.5. The thyroid hormones (T3, T4 and thyroid stimulating hormone) were comparable to that of the control. The ATG (80.7?±?39.3?IU/ml) and ATPO (70.3?±?39.7?IU/ml) antibodies were significantly increased in RA patients compared to the control (21.5?±?6.6?IU/ml and 20.5?±?11.2?IU/ml respectively; p?