Role of cartilage oligomeric matrix protein (COMP) as a prognostic biomarker in follow-up of early rheumatoid arthritis patients: Correlation to musculoskeletal ultrasonographic findings

摘要

Aim of the work To assess the level of serum cartilage oligomeric matrix protein (COMP) in early rheumatoid arthritis (RA) patients and study its relation to disease activity and musculoskeletal ultrasound (MSUS) findings. Patients and methods The study included 40 early RA patients. Disease activity score (DAS28) was assessed. Serum COMP level was measured and MSUS findings of the small joints of hands done at base line and after 6?months of follow up.20 age and sex matched control were included. Results Patients age was 38.8?±?9.3?years; 36 females and 4 males and disease duration 6.7?±?3.5?years. Serum COMP was significantly higher in patients (median 190?U/L; 90–750?U/L) compared to control (90?U/L; 80–130?U/L)(p?