Role of adiponectin and proinflammatory gene expression in adipose tissue chronic inflammation in women with metabolic syndrome

摘要

Background The purpose of this research was to study the gene expression of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), vascular endothelial growth factor A (VEGF-A) and adiponectin (AdipoQ) genes in the visceral (omental, mesenteric) and subcutaneous adipose tissue depots in metabolic syndrome (MS). We studied 23 women with MS, with a mean age of 50.7?±?4.5 years and mean body mass index (BMI) of 45.6?±?9.8 kg/m2. The control group included 10 women, with a mean age of 40.6?±?8.7 years and normal BMI (22.3?±?3.7 kg/m2). The gene expression levels in the omental (OAT), mesenteric (MAT) and subcutaneous (SAT) adipose tissues were assessed by quantitative real-time PCR. Findings Increased gene expression levels of IL-6 and TNF-α were detected in MAT in patients with MS, compared with the control group (p?