Development and evaluation of Ketoprofen loaded biopolymer based transdermal film

摘要

The aim of the present study was to formulate biopolymer based transdermal film loaded with Ketoprofen (KF). Transdermal films were prepared by using sodium locust bean gum (LBG) and Sodium alginate (SA) as biopolymers by varying the blend ratios by solution casting method. The drug loaded membranes were evaluated for thickness, tensile behaviors, content uniformity, transdermal permeation of KF through rat abdominal skin was determined by Franz diffusion cell. In vitro skin permeation profile of optimized formulation was compared with that of KF conventional gel. Carrageen induced rat paw edema model was used to investigate the in vivo performances. Menthol (3%) and glycerin (3%) are used as permeation enhancer and plasticizer, respectively. KF was found to be compatible and stable with the prepared formulation as confirmed by Fourier transform infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC), studies. Invitro release studies revels effectiveness after 24 h when compared with the conventional gel. The film does not shows any signs of edema, erythema or ulceration. From the invitro skin permeation and anti inflammatory activity data it can be concluded that the developed optimized formulation ( F3) has good potential to achieve the transdermal drug delivery of KF for effective therapy.