Effect of dissolution rate by liquisolid compact approach: An overview

摘要

In recent generations the limited solubility of drugs, which are challenging issue for industry during development of the ideal solid dosage unit. To overcome this consequence, liquisolid technique is a novel and promising approach. The technique is based upon the admixture of drug loaded solutions (or) liquid drug with appropriate carrier and coating materials. Addition of the additives improves the technique. The selection of non-toxic hydrophilic solvent, carrier, coating excipients and its ratios are independent of the individual chemical entities. Indirectly it leads to enhance the bioavailability. However, poorly soluble drugs with low dose chemical entities are more ideal to formulate in the above said technique.