Synthesis and antimicrobial evaluation of diversely substituted spirooxindole derivatives

摘要

A series of novel spirooxindole derivatives have been synthesized from isatin, malononitrile, and cyclic 1,3- dicarbonylcompounds through a highly efficient and green one-pot multicomponent reaction using tetrabutylammonium bromide (TBAB) as catalyst in ethanol under reflux condition. The synthesized compounds were evaluated for their antimicrobial activity. Antimicrobial studies showed that all the target compounds processing good antibacterial and antifungal activities.