Potential Role Of Sulfur Nanoparticles As Antitumor And Antioxidant In Mice

摘要

Objectives: The role of elemental sulfur in human nutrition has not been studied extensively. Therefore, this study aimed todetermine of some biochemical effects of sulfur nanoparticles (S-NPs) and emphasize the importance of this element asantioxidant and antitumor agent.Methods: Preparation of sulfur nanoparticles was done throughout. Firstly, the evaluation of their composition and purity byFourier Transform Infrared Spectrometer (FT-IR) analysis. Secondly, The shape and size of S-NPs were investigated by scanningelectron microscopy (SEM) techniques in all S-NPs samples which were prepared with Tetramethylammonium bromide (TMAB)surfactant, Then, Energy-dispersive X-ray spectroscopy (EDS) for the evaluation of their composition and purity, After that theX-Ray Diffraction patterns were measured for prepared S-NPs with TMAB surfactant. Final determination of sulfurnanoparticles antioxidant and antitumor activites in experiment female mice bearing EAC, determination of some molecularmarkers such as P53 and Cytochrome C. Also, histological examinations of liver and kidney tissues were done. Results: This study revealed that sulfur nanoparticles showed high strong antioxidant activity in concentration (5 mg/kg) andantitumor activities as it increase SOD, GPx and TAC production compared to the positive control group. Also showed asignificant increase in p53 and Cytochrome C compared with the positive control group.Conclusion: Sulfur nanoparticles play an important role in improving oxidative stress resulted in significantly increase activityagainst EAC cells, and Also, sulfur nanoparticles reduced most of the pathological alterations induced by Ehrlich ascitescarcinoma cells in mice which confirmed by histopathological examination, this may be supports the suitability of the use ofsulfur nanoparticles as an antioxidant and anticancer agent. Further, more different types of Cancer cells have unique propertiesthat can be exploited by nanoparticles to target this Cancer cell.