Effect of Caesalpinia bonducella extract in pylorus ligation induced ulcers inwistar rats.

摘要

Caesalpinia bonducella (L.) Fleming (Syn. Caesalpinia bonduc (L.) Roxb, Syn. Caesalpinia cristaLinn.), belonging to the family Fabaceae /Caesalpiniaceae, traditionally used in treating ailments of gastrointestinal tract. The phytoconstituents suggest the possible anti-ulcer property of the plant. Based on which, the present study has been conducted to evaluate the effect of Caesalpinia bonducella dry nut extract in Wistar rats. The animals were divided into six groups of 6 animals each. The treatments were administered for 10 days. On day 10, the animals were fasted overnight, the pylorus was ligated and after 19 hours, the animals were sacrificed, gastric contents were removed. The pH, volume, total and free acid of the gastric contents were determined. The stomach was excised and observed for the ulcer index. Treatment with Caesalpinia bonducella dry nut extract significantly decreased the gastric volume, decreased the total and free acids while there was no change in pH. However, there was a significant decrease in the ulcer index. The Caesalpinia bonducella dry nut extract was found to decrease pylorus ligation induced ulcers. The present study had validated the traditional use of Caesalpinia bonducella as an antiulcer agent.