Formulation and development of gastroretentive multi-layer coatedtablets containing Gatifloxacin against H.pylori infection

摘要

Floating multi-layer coated tablets were formulated based on gas formation. The system consists of a drug containing core tablet coated with a protective layer (Hydroxy Propyl Methyl Cellulose-HPMC), a gas forming layer (sodium bicarbonate) and a gas-entrapped membrane, respectively. Eudragit RL 30D was chosen as a gas-entrapped membrane due high water permeability and low CO2 permeability. The obtained tablets showed the buoyancy due to the CO2 gas formation and the gas entrapment by polymeric membrane of Eudragit RL 30D. The effect of formulation variables on floating properties and drug release was investigated. The floating tablets using direct-compressed cores had shorter time to float and faster drug release than those using wet-granulated cores. The increased ratio of sodium bicarbonate to HPMC increased the drug release from the floating tablets while increasing coating level of gasentrapped membrane increased floating lag time. Good floating properties and sustained drug release were achieved. These floating tablets seem to be a promising floating gastroretentive drug delivery system which can be targeted in stomach to eradicate H.pylori infection.