Palmoplantar pustulosis with severe psoriatic nail dystrophy in a patient?receiving etanercept for treatment of ankylosing spondylitis

摘要

Etanercept is a chimeric fusion protein binds and neutralizes soluble tumor necrosis factor (TNF)-α and TNF-β. It is effective in treating many inflammatory diseases, including rheumatoid arthritis, ankylosing spondylitis, and psoriasis. We report a case of paradoxical development of palmoplantar pustulosis (PPP) and nail dystrophy after receiving etanercept to treat ankylosing spondylitis.