Antimicrobial and antioxidant evaluation of a retro spective siddha formulation Dhasalavana dhravagam used for the treatment of infectious disease

摘要

The main objective of the present study is to evalu ate the antimicrobial and antioxidant potential of Dhasalavana dhravagam (DLD) a well-known classical drug selecte d from the Siddha classical literature, “Kannusamiy am Ennum Vaidhya Segaram. The antimicrobial property o f the DLD was studied against Gram-negative and Gra m- positive microorganisms using the agar well diffusi on method. The result of antimicrobial screening st udy projects that the drug DLD exhibited bigger zone of inhibiti on of about 08- 26 mm against Staphylococcus aureus followed by this 09- 25 mm of zone against Klebsiella pneumo nia, 09- 24 mm of zone against Bacillus Subtilis an d 07- 22 mm zone against Salmonella typhimurium at the concentr ation of 250mg/ml. Antioxidant potential of DLD wa s evaluated by using DPPH radical scavenging assay. T he result obtained from the study shows that DLD po ssess potential antioxidant activity (91.3%) relatively n ear to the standard drug. From the study it was con cluded that the drug DLD has promising antimicrobial, antioxidant a ctivity and hence this siddha formulation may serve as a prospective drug for treating several infectious di seases in near future.