Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

摘要

Graphical abstract Display Omitted Highlights ? Gut microbiota has a role in the type 1 diabetes onset. ? Akkermansia municiphila could be a gut permeability bio-indicators. ? Methanobrevibacter smithii is implicated in different metabolic children disease. ? Hierarchical classification of DGGE profile shows difference between cases and controls. ? M. smithii and Simpson index could be considered as predictive bio-indicators of T1DM. Abstract Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.