Is Increased Serum Alkaline Phosphatase Level in Children a Sign of Vitamin D Deficiency or Bone Growth?

摘要

Objective: This study aims to investigate the effects of vitamin D and alkaline phosphatase (AKP) on height. Method: 1887 healthy children were enrolled from May 2014 to December 2014 for the detection of height, AKP, 25(OH)-vitamin D3 [25(OH)D], and serum levels of Calcium (Ca) and Phosphorus (P) at 3 different time points (baseline, 3-month and 6-month). In accordance with the growth speed, the children were divided into the low-speed group (2 cm/3 months) to compare the differences of the above indicators among the groups. Results: The enrolled children all had normal serum Ca, and the calcium-phosphorus product was >40, while 98.5% children exhibited the increased serum phosphorus. The high-speed group exhibited significantly increased AKP concentration, which was statistically significant with the other two groups ( P