Is anti-D immunoglobulin still a frontline treatment option for immune thrombocytopenia?

摘要

A 5-year-old boy presents with platelet count of 2 × 10~(9)/L and clinical and laboratory evidence of immune thrombocytopenia. He has epistaxis and oral mucosal bleeding. Complete blood count reveals isolated thrombocytopenia without any decline in hemoglobin and he is Rh~(+). You are asked if anti-D immunoglobulin is an appropriate initial therapy for this child given the 2010 Food and Drug Administration “black-box” warning.