High Prevalence of Hepatitis B Virus Infection in the Village of Esfandiar in South Khorasan Province, Iran

摘要

Background: Infection with Hepatitis B virus (HBV) is still a leading cause of cirrhosis and hepatocellular carcinoma around the world. Objectives: Having recently received reports of high HBV prevalence in the South Khorasan Province in the Esfandiar village, we aimed to evaluate the prevalence of HBV in this region in comparison to neighboring villages, with associations to risk factors. Methods: This was a cross sectional study that included the Esfandiar village and neighboring villages, Marghoub, and Zenowghan. All of the Esfandiar and certain neighboring villages were summoned and blood sampling was performed along with the completion of a questionnaire. Positivity for HBsAg, anti-HBc along with the seromarkers of HCV and HDV were assayed using ELISA method. Statistical analysis was performed using the SPSS software with chi-square tests, logistic regression, and risk-estimation analysis. Results: From total 1.245 participants, 856, 172, and 217 cases were from the Esfandiar, Marghoub, and Zenowghan villages, respectively. The prevalence of anti-HBc in the Esfandiar, Marghoub, and Zenowghan were 48.7%, 20.3%, and 7.8%, respectively (P-value: 0.001). The figures for HBsAg were 17.8 %, 1.7 %, and 0.5 %, respectively (P-value: 0.001). HBV was more prevalent among those with a history of experimental dentistry, traditional phlebotomy, war veterans, endoscopy, and familial history of HBV. In Esfandiar, prevalence of HBsAg among below and above 22 years- old (beginig of natoinal HB vaccination) were 2.3% and 22.4%, respectively (P-value < 0.001). Conclusions: There was a very high prevalence of HBV in this small endemic region. The result showed the impressive effect of neonatal vaccination on reducing the incidence of hepatitis B, by 89.7%. Thus, the high prevalence requires an urgent consideration of organizing health programs and certain sociocultural behaviors.