TUMOR NECROSIS FACTOR α-308 G/A POLYMORPHISMS AND RISK OF HEPATOCELLULAR CARCINOMA: A META-ANALYSIS (REVIEW ARTICLE)

摘要

Context: Hepatocellular carcinoma (HCC) is a common disorder throughout the world that can develop due to various factors, including genetics. Tumor necrosis factor- a (TNF- a ) is the most frequently studied cytokine related to the risk of developing HCC, and an association between the 308 position of the TNF- a promoter (TNF a -308) and HCCrisk has been confirmed in various reports.Evidence Acquisition: The PubMed, Scopus, and Google Scholar databases were searched through July 12, 2015, for studies on associations between TNF- a 308 and the risk of HCC. To determine this association, odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.Results: A total of 23 case-control studies were investigated, involving 3, 389 cases and 4, 235 controls. The overall conclusion was that the A allele was more frequent in case groups compared to control groups (13.4% vs.8.4%). Thus, the A allele was significantly associated with increased HCC risk (OR=1.77; 95% CI=[1.26-2.50]; P valueConclusions: This meta-analysis indicated that the TNF- a 308 G/A polymorphism is significantly associated with increased susceptibility to HCC. However, to confirm this finding, more studies are needed on TNF- a 308 G/A polymorphisms associated with HCC.