Identification and Quantitative Analysis of 2-Phenylethanol as Major Impurity in Bromadol by HPLC

摘要

Bromadol can serve as a powerful and versatile agent in medicinal chemistry. In this paper, 2-phenylethanol was first identified as a main impurity in commercial Bromadol sample by HPLC. HPLC quantitative analysis method for impurity 2-phenylethanol in Bromadol has also been established for the first time. By our new HPLC analysis method, the impurity 2-phenylethanol was found to be 9.6% by weight. The identified main impurity 2-phenylethanol can be successfully removed by heating under vacuum, which gave an easy way to purify Bromadol for mass production.