Western Lifestyle and Increased Prevalence of Atopic Diseases: An Example from a Small Papua New Guinean Island

摘要

Background Allergic diseases represent an increasing problem in public health in most modern societies as their prevalence has risen markedly during recent decades. Nevertheless, the causes of this increase are not yet fully explained. Objective We investigated the correlation of Western lifestyle pattern in varying intensity to the prevalence of atopic diseases in 5 small villages on Karkar Island, in northeast Papua New Guinea. Methods Two hundred forty-eight native people from 5 villages on tropical Karkar Island have been included in this study. The degree of Western lifestyle was assessed (questionnaire and observation) for each village. The prevalence of atopic diseases was evaluated by personal and family history, physical and dermatological examination, skin prick test (10 allergens), and measurement of total and specific immunoglobulin E levels (20 common allergens). Results The more easily accessible and thus more "modern" and westernized coastal villages showed a significantly higher prevalence of habitants suffering from atopic diseases than a traditional mountain village (6.8% vs 0.0%, P = 0.034, Fisher exact test). A total of 4.4% (11/248) of the examined islanders suffered from an atopic disease. Atopic eczema seems to be absent on Karkar Island. Conclusions The results of this study suggest that so-called Western lifestyle may contribute to the development of atopic diseases.