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Impact of the immune cell population in peripheral blood on response and survival in patients receiving neoadjuvant chemotherapy for advanced gastric cancer

机译:外周血免疫细胞群对晚期胃癌新辅助化疗患者反应和生存的影响

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We aimed to investigate the prognostic value of the immune cells population in peripheral blood from patients with advanced gastric cancer treated with neoadjuvant chemotherapy. A total of 105 patients with advanced gastric cancer were evaluated in this study. Blood samples were collected before and 1 week after the last dose of chemotherapy. The percentage of CD3+, CD3+CD4+, CD3+CD8+, and CD4+CD25+Foxp3+ T cells was assessed using flow cytometry analysis. The relationship between T cell subsets and clinical outcome was evaluated. The percentage of CD3+CD8+ lymphocytes was significantly increased after chemotherapy and CD4+CD25+Foxp3+ regulatory T cells (Tregs) decreased (p = 0.003 and p p = 0.017 and p p = 0.012 and p = 0.048, respectively). Neither CD3+ nor CD3+CD4+ T cells showed significant changes after chemotherapy or correlations with the clinical outcome. The positive correlation between a high CD3+CD8+ T cells or low CD4+CD25+Foxp3+ Tregs and clinical outcome indicates its key role in the prognosis of gastric cancer patients and may serve as a biomarker to identify patients likely to benefit from neoadjuvant chemotherapy.
机译:我们旨在研究新辅助化疗治疗的晚期胃癌患者外周血中免疫细胞群的预后价值。本研究共评估了105例晚期胃癌患者。在最后一次化疗之前和之后1周收集血液样本。使用流式细胞术分析评估CD3 +,CD3 + CD4 +,CD3 + CD8 +和CD4 + CD25 + Foxp3 + T细胞的百分比。评价了T细胞亚群与临床结果之间的关系。化疗后,CD3 + CD8 +淋巴细胞的百分比显着增加,而CD4 + CD25 + Foxp3 +调节性T细胞(Tregs)降低(分别为p = 0.003和p p = 0.017和p p = 0.012和p = 0.048)。化疗后,CD3 +和CD3 + CD4 + T细胞均未显示出明显变化或与临床结局相关。高CD3 + CD8 + T细胞或低CD4 + CD25 + Foxp3 + Treg与临床结果之间的正相关性表明其在胃癌患者预后中的关键作用,并可作为生物标志物来鉴定可能受益于新辅助化疗的患者。

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