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首页> 外文期刊>Trials >Community-based trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial
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Community-based trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial

机译:社区筛查沙眼衣原体以预防盆腔炎的试验:POPI(预防盆腔感染)试验

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Background Pelvic inflammatory disease (PID) is common and can lead to tubal factor infertility, ectopic pregnancy or chronic pelvic pain. Despite major UK government investment in the National Chlamydia Screening Programme, evidence of benefit remains controversial. The main aim of this trial was to investigate whether screening and treatment of chlamydial infection reduced the incidence of PID over 12 months. Secondary aims were to conduct exploratory studies of the role of bacterial vaginosis (BV) in the development of PID and of the natural history of chlamydial infection. Design Randomised controlled trial with follow up after 12 months. Setting non-healthcare Common rooms and lecture theatres at 20 universities and further education colleges in Greater London. Participants 2500 sexually active female students were asked to complete a questionnaire on sexual health and provide self-administered vaginal swabs and smears. Intervention Vaginal swabs from intervention women were tested for chlamydia by polymerase chain reaction (PCR) and those infected referred for treatment. Vaginal swabs from control women were stored and analysed after a year. Vaginal smears were Gram stained and analysed for BV. Main outcome measure Incidence of clinical PID over 12 months in intervention and control groups. Possible cases of PID will be identified from questionnaires and record searches. Confirmation of the diagnosis will be done by detailed review of medical records by three independent researchers blind to whether the woman is in intervention or control group. Trial registration Clinical Trials NCT 00115388
机译:背景盆腔炎(PID)很常见,可导致输卵管因素不孕,异位妊娠或慢性盆腔疼痛。尽管英国政府在国家衣原体筛查计划中投入了大量资金,但有关获益的证据仍存在争议。该试验的主要目的是调查筛查和治疗衣原体感染是否能降低12个月内PID的发生率。次要目的是进行细菌性阴道病(BV)在PID发生过程中的作用以及衣原体感染自然史的探索性研究。设计随机对照试验,并在12个月后进行随访。在大伦敦的20所大学和继续教育学院中设置非医疗保健公共休息室和演讲厅。参与者要求2500名性活跃的女学生填写有关性健康的问卷,并提供自行管理的阴道拭子和涂片。干预通过聚合酶链反应(PCR)对来自干预妇女的阴道拭子进行衣原体检测,并将那些感染者转诊进行治疗。一年后,储存和分析对照女性的阴道拭子。对阴道涂片进行革兰氏染色并分析BV。主要结果指标干预组和对照组中超过12个月的临床PID发生率。可能通过问卷调查和记录搜索来确定可能的PID病例。将由三名独立于该妇女是干预组还是对照组的独立研究人员对病历进行详细审查,以确认诊断。试验注册临床试验NCT 00115388

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