Liver Transplantation in a Patient with Acquired Dysfibrinogenemia Who Presented with Subdural Hematoma: A Case Report

摘要

Fibrinogen is one of the most abundant proteins in the blood; normallevels range from 200 to 400 mg/dL. Fibrinogen is synthesized inthe liver and is essential for the clotting of blood. It also bindsto platelets, supports aggregation, and plays an important rolein wound healing. Fibrinogen deficiencies can be caused bydecreased levels (hypo- or afibrinogenemia) or defective function(dysfibrinogenemia). Dysfibrinogenemia may either be autosomaldominantly inherited or acquired and it can manifest as bleeding orthrombotic events, or in some cases both simultaneously. Situationscausing acquired dysfibrinogenemia include chronic liver disease,malignancies, and autoimmune diseases. Herein, we report a livertransplant recipient with dysfibrinogenemia who presented withsubdural hematoma due to liver cirrhosis.