Diagnostic Accuracy of Interleukin-6, Interleukin-8, and Interleukin-10 for Predicting Bacteremia in Children with Febrile Neutropenia

摘要

Despite improvements in diagnosis and treatment, infections arestill a major cause of morbidity and mortality in children withfebrile neutropenia. In the majority of febrile episodes, the sourceof infection cannot be defined. In this study, we aimed to identifythe earlier predictors of bacteremia/fungemia and a useful cytokineto identify the source of infection and to discriminate the patientswith culture-confirmed bacterial/fungal infection. The most sensitivecytokine was interleukin (IL)-10 and the most specific was IL-8 inpredicting culture-confirmed cases. IL-8 had greater sensitivity andspecificity in determination of gram-negative bacterial infectionswith a higher negative predictive value; therefore, IL-8 can be usedparticularly to rule out gram-negative bacterial infections. IL-6, IL-8, and IL-10 circulating levels were shown to be higher in cases ofinfection. Further studies are needed to recommend a routine practicefor predicting culture-confirmed bacterial infections.