PROPOFOL-RELATED INFUSION SYNDROME IN A GERIATRIC PATIENT FOLLOWING THE USE OF PROPOFOL IN LOW DOSES AND SHORT DURATION, DURING AND AFTER CARDIAC SURGERY: A CASE REPORT

摘要

Propofol, is a potent short-acting intravenous sedative-hypnotic agent used for induction and maintenance of general anesthesia and to provide continuous sedation in the intensive care unit. Propofol-related infusion syndrome is a rare yet often fatal syndrome associated with the continuous infusion of propofol. It is characterized by severe metabolic acidosis, cardiac failure, bradycardia, myoglobinuria and renal failure. Hereby we present a case of propofol-related infusion syndrome which developed in 74 years of age patient, following coronary artery by-pass grafting and aortic valve replacement surgery in the early postoperative period. Low dose propofol was used both intraoperatively and in the intensive care unit postoperatively. The patient developed severe lactic acidosis, oliguria and bradycardia requiring cardiac pacing in the sixth hour postoperatively. Lactic acidosis and clinical condition improved promptly within a few hours, following the discontinuation of propofol infusion.