A validation of the diathesis-stress model for depression in Generation Scotland

摘要

). However, in those participants who reported no recent SLE, a higher PRS appeared to increase the risk of depressive symptoms in men (β?=?0.082, p?=?0.016) but had a protective effect in women (β?=?-0.061, p?=?0.037). This difference was nominally significant (p?=?0.017). Our study reinforces the evidence of additional risk in the aetiology of depression due to GxE effects. However, larger sample sizes are required to robustly validate these findings.