Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics

摘要

Second-generation antipsychotics (SGAs) are increasingly being used to treat children with a variety of psychiatric illnesses. Metabolic syndrome (MetS), a risk factor for cardiovascular disease, is a side-effect of SGA-treatment. We conducted a cross-sectional study and assessed the association of the methylenetetrahydrofolate reductase (MTHFR) C677T variant with features of MetS in SGA-treated (n=105) and SGA–na?ve (n=112) children. We targeted the MTHFR C677T variant, because it is associated with risk for cardiovascular disease, and features of MetS in adults without psychiatric illness. MetS in children is based on the presence of any three of the following: waist circumference 90th percentile for age and sex; plasma triglyceride 1.24?mmol?l?1; plasma high-density lipoprotein-cholesterol 1.03?mmol?l?1; systolic or diastolic blood pressure 90th percentile for age, sex, and height; and fasting glucose 5.6?mmol?l?1. We found that 15% of SGA-treated children had MetS compared with 2% of SGA-na?ve children (OR 8.113, PMTHFR C677T variant on psychiatric diagnosis was observed. The MTHFR 677T allele was associated (PMTHFR 677T allele and diastolic blood pressure Z-scores (P=0.001) and fasting plasma glucose (PMTHFR C677T variant may have a role in the development of MetS features in SGA-treated children.. ? 2012 Macmillan Publishers Limited