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Molecular and Physiological Effects on the Small Intestine of Weaner Pigs Following Feeding with Deoxynivalenol-Contaminated Feed

机译:饲喂脱氧雪茄烯醇污染的饲料对断奶仔猪小肠的分子和生理影响

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We intended to assess how exposure of piglets to deoxynivalenol (DON)-contaminated feed impacted their growth, immune response and gut development. Piglets were fed traditional Phase I, Phase II and Phase III diets with the control group receiving 0.20–0.40 ppm DON (referred to as the Control group) and treatment group receiving much higher level of DON-contaminated wheat (3.30–3.80 ppm; referred to as DON-contaminated group). Feeding a DON-contaminated diet had no impact on average daily feed intake (ADFI) ( p 0.08) or average daily gain (ADG) ( p 0.10) but it did significantly reduce body weight over time relative to the control piglets ( p 0.05). Cytokine analysis after initial exposure to the DON-contaminated feed did not result in significant differences in serum interleukin (IL) IL1β, IL-8, IL-13, tumor necrosis factor (TNF)-α or interferon (IFN)-γ. After day 24, no obvious changes in jejunum or ileum gut morphology, histology or changes in gene expression for IL-1β, IL-6, IL-10, TNFα, or Toll-like receptor (TLR)-4 genes. IL-8 showed a trend towards increased expression in the ileum in DON-fed piglets. A significant increase in gene expression for claudin (CLDN) 7 gene expression and a trend towards increased CLDN 2-expression was observed in the ileum in piglets fed the highly DON-contaminated wheat. Because CLDN localization was not negatively affected, we believe that it is unlikely that gut permeability was affected. Exposure to DON-contaminated feed did not significantly impact weaner piglet performance or gut physiology.
机译:我们打算评估仔猪暴露于被脱氧雪腐烯醇(DON)污染的饲料的方式如何影响仔猪的生长,免疫反应和肠道发育。给仔猪喂食传统的I,II和III期饲料,对照组接受0.20–0.40 ppm DON(称为对照组),治疗组接受更高水平的DON污染的小麦(3.30–3.80 ppm;参照)作为受DON污染的人群)。饲喂受DON污染的日粮对平均日采食量(ADFI)(p <0.08)或平均日增重(ADG)(p> 0.10)没有影响,但与对照仔猪相比,随着时间的推移体重确实显着降低(p <0.05)。初次暴露于受DON污染的饲料后的细胞因子分析未导致血清白介素(IL)IL1β,IL-8,IL-13,肿瘤坏死因子(TNF)-α或干扰素(IFN)-γ的显着差异。第24天后,空肠或回肠的形态,组织学无明显变化,IL-1β,IL-6,IL-10,TNFα或Toll样受体(TLR)-4基因的基因表达也没有变化。 IL-8显示在DON喂养的仔猪回肠中表达增加的趋势。在饲喂高度受DON污染的小麦的仔猪的回肠中,观察到claudin(CLDN)7基因表达的基因表达显着增加,并且回肠CLDN 2表达增加。由于CLDN的定位没有受到负面影响,因此我们认为肠道通透性不太可能受到影响。暴露于受DON污染的饲料不会显着影响断奶仔猪的生产性能或肠道生理。

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