In vitro studies of Enamel Matrix Derivative In Terms of Periodontal Wound Healing and Periodontal Regeneration

摘要

Periodontal disease results in the loss of attachment apparatus. An increasing effort has been placed on seeking procedures and materials to promote the regeneration of this tissue. An extract of embryonic enamel matrix, termed 'Enamel Matrix Derivative' (EMD), is thought to induce mesenchymal cells to mimic the processes that take place during the development of the root and periodontal tissues, suggesting a promising material which can push the periodontal regeneration cascade forwards by means of several suggested mechanisms. The aim of this paper is to deepen the reader's knowledge of the in vitro effects of EMD in terms of periodontal wound healing and periodontal regeneration. Different features of EMD, the effect of EMD on the cells that are related to periodontal regeneration and the effect of EMD on other cell types are demonstrated in this review. It was concluded that EMD regulates multiple cell types and enhances several cellular mechanisms of periodontal ligament cells. In contrast to its effects on mesenchymal cells, EMD appears to inhibit the proliferation and growth of epithelial cells. The greatest effect of EMD has been shown to be on mature cells, suggesting that it may not be capable of controlling the entire process of periodontal regeneration.