Meta-analysis for efficacy of modified Zhenwu Decoction combined with western medicine in treatment of heart failure

摘要

Abstract Objective: To carry out a systematic evaluation of the efficacy of modified Zhenwu Decoction combined with western medicine in the treatment of heart failure. Methods: Literature was retrieved in China Knowledge Resource Integrated Database (CNKI), Chinese scientific journal database (VIP), Wanfang Data Resource System (WANFANG DATA), PubMed and other traditional Chinese medicine related periodicals by retrieval methods of subject terms combined with free words and computer retrieval combined with manual retrieval. Literature was screened strictly according to the inclusion criteria.The quality of the included literature was evaluated according to the quality standard of Jadad scale and Cochrane collaboration network bias risk assessment tool. The literature data was extracted. RevMan5.3 software was used to analyze data and the curative effect of modified Zhenwu Decoction combined with western medicine was objectively evaluated. Results: The response rate of the experimental group was better than that of the control group [OR = 3.69，95% IC (2.36，5.79)]. The value of EF in the experimental group was higher than that in the control group after treatment [MD = 5.85, 95% IC (3.90, 7.79) ]. The Lee, score of the experimental group was lower than that of the control group after treatment [MD = -1.37, 95% IC (-2.23, -0.52) ]. The value of BNP in the experimental group was less than that in the control group after treatment [MD = -114.48, 95%IC (-186.28, -42.68)]. The life quality score in the experimental group was less than that of the control group after treatment [MD = -8.44, 95%IC (-11.73, -5.15)]. Conclusion: The curative effect of modified Zhenwu Decoction combined with western medicine in the treatment of heart failure is better than the simple western medicine treatment．So modified Zhenwu Decoction combined with western medicine in the treatment of heart failure is worthy of clinical promotion. However, the results of this study still need further validation by more high quality randomized double blind controlled clinical trial because the overall quality of the research included.