Abstract Objective: To analyze the clinical efficacy of Traditional Chinese Medicine (TCM) combined with chemotherapy in the treatment of primary liver cancer on the basis of meta analysis software. Method: Retrieval randomized controlled trials (RCT) of TCM combined with chemotherapy in the treatment of the liver cancer from the network database (such as MEDLINE, EMBASE, PUBMED, Chinese CNKI database, Wanfang database, VIP database etc.). The retrieval period was from January 2011 to July 2017. Results: A total of 16 RCT studies were included and involving 1873 patients, with 949 patients in the treatment (TCM with chemotherapy) group and 924 patients in the control group (chemotherapy alone). Meta analysis results suggest that TCM combined with chemotherapy in the treatment of primary hepatocellular carcinoma can improve curative effect, improve the degree of ascites of patients, improve the quality of life of patients and alleviate chemotherapy side effects. Conclusion: TCM combined with chemotherapy in the treatment of primary liver cancer is helpful to improve the short term curative effect, improve the quality of life of patients, and alleviate the toxic and side effects.
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