Early enteral nutrition supplemented with probiotics improved the clinical outcomes in patients with severe head injury: protocol for a meta-analysis of randomized controlled trials

摘要

Abstract HighlightsClinical trials have shown that early enteral nutrition supplemented with probiotics may have potential of benefit for SHI patients; however, conflicting conclusion obstacle the decision-making. This protocol will provide approach to resolve this issue.Editor’s SummaryAlthough early enteral nutrition combined with probiotics were supposed to have potential of treating SHI patients, conclusive results have not yet been generated. This protocol will address this issue with quantitative synthesis method.ABSTRACTObjective: The aim of this systematic review of randomized controlled trials (RCTs) is to determine the effects of early enteral nutrition supplemented with probiotics on clinical outcomes in patients with SHI. Methods and analysis: A systematic search will be carried out in PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI), WanFang database, and Chinese Biomedical Literature (CBM) in order to identify the randomized controlled trials (RCTs) investigated the potential of early enteral nutrition supplemented with probiotics on patients with severe head injury, as well as we will also manually check the bibliographies of eligible studies and topic-related reviews. We will assign two investigators to independently search all potential citations, extracted data, and appraised risk of bias accordingly, and then STATA software version 12.0 will be used to statistically analyze all data.Ethics and dissemination: The ethics approval and patient written informed consent will not be required because all analyses in the present study will be performed based on data from published studies. We will submit our systematic review to a peer-reviewed scientific journal for publication.