ClC-2 Channels in Erythrocytes

摘要

ClC-2 is a ubiquitously expressed plasma membrane Cl- channel that reportedly controls the ionic environmentin mouse retina and testis. Beyond that, ClC-2 might sense cellular energy status and cellular stress by its carboxyterminalcystathionine-beta-synthase (CBS) domains and by its molecular interaction with the heat shock protein Hsp90,respectively. In mature human and mouse erythrocytes, ClC-2 is activated by oxidative stress and by malaria infection.This article describes possible function of erythrocyte ClC-2 channels for the programmed death of oxidatively injurederythrocytes and for the regulatory volume decrease of malaria-infected erythrocytes.