Despite the increased use of Simulation based Optimization, the design of facility layout is challenged by high levels of uncertainty associated with new production processes. Addressing this issue, this paper aims to understand the conceptual modeling activities of Simulation-based Optimization for facility layout design in conditions of high uncertainty. Based on three in-depth case studies, the results of this paper show how characterization criteria of production systems can be used in conceptual modelling to reduce uncertainty. These results may be essential to support managers and stakeholders during the introduction of new production processes in the design of facility layouts.
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