Pathomorphosis of Uterine Myomas in Women

摘要

Taking stroma (ECM-extracellular matrix) and not tumour parenchyma as a criterion of categorization, the tumourscan be divided into two groups, i.e. those which produce stroma (non-epithelial malignant tumours) or sarcomasand the tumours which take advantage of the local tissue stroma (malignant epithelial tumours) or carcinomas. Involvementof stroma is noted also within the reciprocal relationship between stroma and tumour cells, which has been describedin detail on the example of uterine myoma. ECM also "collaborates" with CAM (cell adhesion molecules), particularly indevelopment of neoplastic metastases.Pathomorphosis of myomas, myosarcomas and of "stromal" uterine tumours was described with particular attention givento differential diagnosis and the resulting clinic predictive and prognostic implications. A probable mechanism of neoplasiabased on dissipative structures of cells was presented and introduction of a disoric zone of a tumour, i.e. of a marginalzone between the tumour and the morphologically normal tissue was suggested. The zone seems extremely important inprediction and prognosis related to relapse and/or tumour metastases.