The Renin Angiotensin System and the Metabolic Syndrome

摘要

The renin angiotensin system (RAS) is important for fluid and blood pressure regulation. Recent studiessuggest that an overactive RAS is involved in the metabolic syndrome. This article discusses recent advances on how geneticalteration of the RAS affects cardiovascular and metabolic phenotypes, with a special emphasis on the potential roleof angiotensin-independent effects of renin.