Home Blood Pressure Measurement in the Morning Related to Cancer inPatients with Type 2 Diabetes Mellitus: 10 Years-Term Results of a LongitudinalStudy and Cancer

摘要

Previous longitudinal studies have demonstrated that blood pressure measurements at home (HBP) in the wakening-up display stronger predictive power for death, and vascular complications in patients with type 2 diabetes mellitus(T2DM) than clinic blood pressure measurements (CBP). The leading cause of death was cancer. Patients with T2DMhave associated with cancer, and high CBP is a risk factor for cancer. Therefore, this study investigated whether HBPor CBP is related to cancer event in patients with T2DM for 10 years. At baseline, 400 Japanese patients with T2DMwere classified as hypertensive (HT) or normotensive (NT) based on HBP and CBP. Mean (± SD) duration was 95 ± 35months. Primary and secondary endpoints were death and cancer, respectively. Differences in outcome between HT andNT were analyzed using survival curves from Kaplan-Meier analysis and log-rank testing. Associated risk factors wereassessed using Cox proportional hazards. On basis of HBP, death and event of cancer were significantly higher in HT thanin NT. The leading cause of death was cancer. On basis of CBP, there was no significant difference in the incidence ofdeath and event of cancer between patients with HT and NT at baseline. Associated risk factor for cancer was T2DM.Home morning HT may be reflected more keenly state of cancer than clinic HT, which may be superior to clinic NT.When we meet with such patients, it is important that cancer may be one of many causes for morning HT in Japanese patientswith T2DM.