In Vitro Susceptibility of Diabetic Wound Bacteria to Mixtures of Honey,Commiphora molmol and Nigella sativa

摘要

The search for an ideal dressing for diabetic foot wounds/ulcers is still ongoing. Patients' preferences of suchdressing usually relate to their local cultural background. The aim of this study was to evaluate the antibacterial effectivenessof some natural herbal medicines and honey mixtures on clinical isolates from diabetic wounds. Six mixtures consistingof honey, Commiphora molmol and Nigella sativa at different concentrations have been prepared (NP1 to NP6). Allmixtures were effective against the tested bacterial isolates from three different diabetic food wound patients at 50%. NP4and NP5 were the most effective as antibacterial for the examined seven bacterial isolates among the mixtures as theywere able to kill bacteria at 25% after 24 hours of incubation. An over additive action has been noticed between honey andherbal medicines. The effectiveness of mixtures was dose-dependent of Commiphora molmol; NP5 contained the highestamount of the later. Further research is needed to elucidate and optimize the effective combination of these naturalproducts in clinical practice.