Can a High W-6/W-3 Fatty Acid Ratio in The Tissues Predispose Infertility?

摘要

Mediterranean diet appears to be protective and Western diet may be a risk factor for emergence of noncommunicablediseases (NCDS), including infertility. Inflammation is the most important manifestation and risk factorfor NCDs which can be prevented by increased intake of Mediterranean foods rich in omega 3 fatty acids (w-3). The biochemicalcontents of sperm and seminal fluid as well as of egg coating is also imperative in the mechanism of fertilization. Progesterone is known to activate CatSper, (cation channel of sperm) the principal Ca+2 channel of the spermflagellum which is important in fertilization. The receptors on the external cell membrane to which progesterone bindsmay be under the influence of various nutrients. The present review is focused on the significance of w-6 to w-3 ratio onthe motility of sperms. Majority of cytoprotective neutraceuticals including w-3 fatty acids and Coenzyme Q 10 (CoQ10)are present in the mitochondria cell membranes. Since composition of the spermatozoa may be important in infertility, thisposes the possibility that w-6/w-3 ratio of the spermatozoa and seminal fluid can influence progesterone activity and itssensing by the Ca+2 channel.Recent studies demonstrated that the CatSper channel serves as a novel progesterone receptorthat can mediate a fast, non-genomic effect of progesterone at the level of the sperm plasma membrane. Further studies arenecessary to find out the role of w-6/w-3 ratio and CoQ10 levels on Ca+2 channels of the sperm, in the seminal fluid and ova.