Neuroprotective Drugs in Traumatic CNS Injury

摘要

Despite extensive experimental research, the numbers of neuroprotective drugs that have proven efficacyfollowing treatment of patients with traumatic CNS injuries still remain meager. It would be worthwhile to emphasize thatmajority of the victims are mostly in the second or third decades of their lives. A survey on the neuroprotective moleculesthat has been tested experimentally and subsequently tried clinically has been found somewhat beneficial. In the presentreview, we consolidated the updates on a number of such drugs, which hold promise for therapy of traumatic CNSinjuries. Two such agents, endogenous molecules estrogen and melatonin have been under investigation in our laboratoryfor their efficacy in experimental spinal cord injury in rats.