Cytokines Levels in Children Affected by Atopic and Nonatopic Eczema

摘要

Patients with atopic eczema present higher serum levels of total IgE and different pattern of cytokines, comparedto nonatopic eczematous patients. This study aimed to evaluate serum levels of IL-2, IL-4, IL-5, IL-10, IFNγ, TNFαin eczematous children in relation to atopic and nonatopic form. We enrolled 45 eczematous children and 12 controls. TotalIgE and specific IgE against principal food and inhalant allergens were evaluated by UniCap1000 and levels of cytokinesby Cytometric Bead Array System. The geometric means of levels of IL-4 were higher in eczematous patients thancontrols (P=0.036). Serum levels of IL-10 and IFNγ were higher in nonatopic eczematous children than in atopic eczematouspatients and controls (P= 0.004, P= 0.003). Our data confirm that cytokines may play an important role in the pathogenesisof eczema: nonatopic eczema seems to be characterized by increased levels of IL-10 and IFNγ compared to atopicform.