Antihyperlipidemic Activity of Methanolic and Aqueous Extracts of Garcinia Mangostana in Poloxamer 407-Induced Acute Hyperlipidemic Rats

摘要

Garcinia mangostana is a tropical plant found commonly in South East Asia. This plant possesses anti-inflammatory, antibacterial,antiulcer, antiseptic and also showed prevention against oxidative damage of low density lipoprotein (LDL). The present studyaimed to evaluate the antihyperlipidemic activity of the methanolic and aqueous extracts of various parts of G. mangostana inpoloxamer 407- induced hyperlipidemic rats. The aqueous extracts exhibited larger reduction in total cholesterol, triglycerides, andLDL and high density lipoprotein (HDL) levels compared to methanolic extracts. Aqueous extract of leaves showed significantreduction of 62.95% and 82.08% in total cholesterol (p<0.001) and triglycerides (p<0.001) levels, respectively compared tohyperlipidemic control at 58 hour after hyperlipidemia induction. Likewise, aqueous extract of stem exhibited significant reductionof 74.97% and 78.50% in total cholesterol (p<0.001) and triglycerides (p<0.001) levels, respectively at 58 hour afterhyperlipidemia induction. In conclusion, aqueous extract of stem showed highest reduction of total cholesterol while aqueousextract of leaves showed highest reduction of triglycerides compared to hyperlipidemic control group. These results warrant furtherinvestigation on lipids lowering capacity of these extracts in the high fat diet-induced chronic hyperlipidemic rat model..