Effects of Proteasome Inhibitors on the Nucleolar Size of Porcine Oocytes

摘要

During the final stage of oocyte growth, the morphology of the oocyte nucleoli changes into a compact structure. The objective of this study was to determine the involvement of the proteasome, which is a large protein complex responsible for degrading intracellular proteins, in the nucleolar compaction. The mean nucleolar diameter of growing porcine oocytes (about 100 μm in diameter) was larger than that of fully grown (120 μm) oocytes (15.5 ± 0.3 vs. 13.2 ± 0.1 μm, P