The Role of Deformable Liposome Characteristics on Skin Permeability ofMeloxicam: Optimal Transfersome as Transdermal Delivery Carriers

摘要

The role of deformable liposomes characteristics on skin permeability has evoked considerable interest, sincethe articles reporting the effectiveness of transfersomes for skin delivery were increasingly published. Several reportsfocus on the effect of formulation factor which directly affected the transfersome’s skin permeability. However, the effectof formulation factors was not fully understood as the contradictory results. To clarify this problem, the reliable statisticaltechniques, excellent experimental design and systematical variation were used in this study. Transfersomes loadedmeloxicam containing controlled amount of phosphatidylcholine (PC), cholesterol (Chol), type of surfactant (hydrophilicpart, lipophilic part ) were prepared and investigated for the physicochemical characteristics (e.g., size, size distribution,charge, elasticity, drug content, morphology) and skin permeability. The results indicated that the transfersome containing10% cholesterol, 29% cetylpyridinium chloride (cationic surfactant) with 16 carbons chain length and 10% meloxicamwas the optimal formulation for meloxicam transdermal delivery carrier. The skin permeation of meloxicam in noveltransfersome formulation was higher than classical transfersomes, conventional liposomes and meloxicam saturatedsuspension. Thus, our finding provided important fundamental information for developing novel deformable liposomesfor transdermal drug delivery, especially transfersomes containing surfactant systems.