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The dynamics underlying pseudo-plateau bursting in a pituitary cell model

机译:垂体细胞模型中伪高原爆发的动力学

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Pituitary cells of the anterior pituitary gland secrete hormones in response to patterns of electrical activity. Several types of pituitary cells produce short bursts of electrical activity which are more effective than single spikes in evoking hormone release. These bursts, called pseudo-plateau bursts, are unlike bursts studied mathematically in neurons (plateau bursting) and the standard fast-slow analysis used for plateau bursting is of limited use. Using an alternative fast-slow analysis, with one fast and two slow variables, we show that pseudo-plateau bursting is a canard-induced mixed mode oscillation. Using this technique, it is possible to determine the region of parameter space where bursting occurs as well as salient properties of the burst such as the number of spikes in the burst. The information gained from this one-fast/two-slow decomposition complements the information obtained from a two-fast/one-slow decomposition.
机译:垂体前叶的垂体细胞响应电活动模式分泌激素。几种类型的垂体细胞会产生短暂的电活动,比促发激素释放的单个峰值更有效。这些脉冲称为伪高原脉冲,不同于在神经元中进行数学研究的脉冲(高原脉冲),用于高原脉冲的标准快慢分析用途有限。使用具有一个快速变量和两个缓慢变量的另一种快速慢速分析,我们表明伪高原爆发是卡纳德感生的混合模式振荡。使用这种技术,可以确定发生突发的参数空间区域以及突发的显着特性,例如突发中的尖峰数。从此一快/两慢分解中获得的信息补充了从二快/一慢分解中获得的信息。

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