Plasma Estrogen Levels, Estrogen Receptor Gene Variation, and Ischemic Arterial Disease in Postmenopausal Women: The Three-City Prospective Cohort Study

摘要

Background:In older postmenopausal women, high levels of endogenous estrogen have been related to adverse health outcomes including ischemic arterial disease (IAD). Whether estrogen receptor-α ( ESR1 ) and -β ( ESR2 ) polymorphisms modulate the effects of estrogens on IAD has not been investigated.