The Role of Vitamin D Receptor in Innate and Adaptive Immunity: A Study in Hereditary Vitamin D–Resistant Rickets Patients

Dov Tiosano; Gizi Wildbaum; Vardit Gepstein; Oleg Verbitsky; Yosef Weisman; Nathan Karin; Amos Eztioni

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The Role of Vitamin D Receptor in Innate and Adaptive Immunity: A Study in Hereditary Vitamin D–Resistant Rickets Patients

机译：维生素D受体在先天和适应性免疫中的作用：遗传性抵抗维生素D的Ri病患者的一项研究

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Context:Vitamin D has regulatory effects on innate and adaptive immunity. Curiously, hereditary vitamin D–resistant rickets (HVDRR) patients show no increased incidence of infectious or autoimmune diseases.

机译：背景：维生素D对先天性和适应性免疫具有调节作用。奇怪的是，遗传性维生素D抗性病（HVDRR）患者的感染性或自身免疫性疾病发病率没有增加。

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《The journal of clinical endocrinology and metabolism 》 |2013年第4期| 共9页
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Dov Tiosano; Gizi Wildbaum; Vardit Gepstein; Oleg Verbitsky; Yosef Weisman; Nathan Karin; Amos Eztioni;
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1. Enhanced coactivator binding and transcriptional activation of mutant vitamin d receptors from patients with hereditary 1,25-dihydroxyvitamin d-resistant rickets by phosphorylation and vitamin d analogs. [J] . Liu Y, Shen Q, Malloy PJ, Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research . 2005 ,第9期

机译：通过磷酸化和维生素D类似物增强遗传性1,25-二羟基维生素D抗性病患者的突变维生素D受体的共激活因子结合和转录激活。
2. Identification of a novel nonsense mutation in the ligand-binding domain of the vitamin d receptor gene and clinical description of two greek patients with hereditary vitamin d-resistant rickets and alopecia. [J] . Anna Papadopoulou, Evangelia Bountouvi, Evangelia Gole, Hormone research in p?diatrics . 2014 ,第3期

机译：维生素D受体基因的配体结合域中一个新的无意义突变的鉴定和两名患有遗传性维生素D抗性病和脱发的希腊患者的临床描述。
3. Report of two unrelated patients with hereditary vitamin D resistant rickets due to the same novel mutation in the vitamin D receptor. [J] . Aljubeh JM, Wang J, Al Remeithi SS, Journal of pediatric endocrinology & metabolism: JPEM . 2011 ,第9a10期

机译：两名不相干的遗传性维生素D抗性resistant病患者的报告，原因是维生素D受体具有相同的新突变。
4. Vitamin D Signaling in the Bovine Mammary Gland is part of the Innate Immune Response to Bacterial Pathogens [C] . Corwin D. Nelson, Timothy A. Reinhardt, John D. Lippolis Annual Meeting of the National Mastitis Council . 2010

机译：牛乳腺中的维生素D信号传导是对细菌病原体的先天免疫应答的一部分
5. Role of vitamin D receptor and vitamin D binding protein restriction fragment length polymorphisms in determining dose response to vitamin D: A randomized double blind placebo controlled trial [D] . Sai, Adarsh. 2011

机译：维生素D受体和维生素D结合蛋白限制性片段长度多态性在确定对维生素D的剂量反应中的作用：一项随机双盲安慰剂对照试验
6. Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets [O] . David Feldman, Peter J Malloy 2014

机译：维生素D受体和遗传性维生素D抗性rick病的突变
7. The Role of Vitamin D Receptor in Innate and Adaptive Immunity: A Study in Hereditary Vitamin D–Resistant Rickets Patients [O] . Dov Tiosano, Gizi Wildbaum, Vardit Gepstein, 2013

机译：维生素D受体在先天和适应症免疫中的作用：遗传维生素D抗性佝偻病患者的研究

The Role of Vitamin D Receptor in Innate and Adaptive Immunity: A Study in Hereditary Vitamin D–Resistant Rickets Patients

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