Expression of Type 2 Orexin Receptor in Human Endometrium and Its Epigenetic Silencing in Endometrial Cancer

摘要

Context:Orexins A and B are neuropeptides that bind and activate 2 types of receptors. In addition to direct action in the brain, the orexinergic system has broader implications in peripheral organs, and it has been proposed to have a role in the induction of apoptosis. There are very few data on the endometrium.