Glucokinase Activators AZD6370 and AZD1656 Do Not Affect the Central Counterregulatory Response to Hypoglycemia in Healthy Males

Ensio Norjavaara; Hans Ericsson; Folke Sj?berg; Maria Leonsson-Zachrisson; Mikaela Sj?strand; Linda A. Morrow; Marcus Hompesch

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Glucokinase Activators AZD6370 and AZD1656 Do Not Affect the Central Counterregulatory Response to Hypoglycemia in Healthy Males

机译：葡萄糖激酶激活剂AZD6370和AZD1656不影响健康男性对低血糖的中央反调节反应

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Context:Glucokinase is expressed in the hypothalamus, but effects of glucokinase activators (GKAs) on counterregulatory responses to hypoglycemia are unknown.

机译：背景：葡萄糖激酶在下丘脑中表达，但葡萄糖激酶激活剂（GKA）对低血糖的反调节反应的作用尚不清楚。

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《The journal of clinical endocrinology and metabolism》 |2012年第9期|共7页
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Ensio Norjavaara; Hans Ericsson; Folke Sj?berg; Maria Leonsson-Zachrisson; Mikaela Sj?strand; Linda A. Morrow; Marcus Hompesch;
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1. Pharmacodynamic effects of the oral glucokinase activator AZD6370 after single doses in healthy volunteers assessed with euglycaemic clamp [J] . Diabetes, obesity & metabolism . 2013,第1期

机译：单次口服口服葡萄糖激酶激活剂AZD6370在健康志愿者中的正常血糖夹具评估
2. Hypoglycemia-Associated Autonomic Failure in Healthy Humans: Comparison of Two vs Three Periods of Hypoglycemia on Hypoglycemia-Induced Counterregulatory and Symptom Response 5 Days Later [J] . A. Moheet, A. Kumar, L. E. Eberly, The journal of clinical endocrinology and metabolism . 2014,第2期

机译：与健康人低血糖相关的自主神经功能衰竭：5天后两，三个时期的低血糖对低血糖引起的反调节和症状反应的比较
3. Effects of Antecedent GABA^sub A^ Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans [J] . Maka S Hedrington Stephnie Farmerie Andrew C Ertl Zhihui Wang Donna B Tate Stephen N Davis Diabetes . 2010,第4期

机译：前阿片唑仑激活GABA ^ sub A ^对健康人低血糖反应的反调节作用
4. Optimization of Methylene Blue Adsorption via Functionalized Activated Carbon Using Response Surface Methodology with Central Composite Design [C] . Nabilah Saafie, Mohamad Fakhrul Ridhwan Samsudin, Suriati Sufian International Conference on Material Engineering and Application . 2020

机译：中央复合设计响应面法通过官能化活性炭优化亚甲基蓝吸附
5. Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia [D] . Diggs-Andrews, Kelly Annette 2010

机译：脑胰岛素作用调节下丘脑葡萄糖感应和对低血糖的反应反应
6. Effects of Antecedent GABAA Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans [O] . Maka S. Hedrington, Stephnie Farmerie, Andrew C. Ertl, 2010

机译：先前的GABAA激活与阿普唑仑对健康人对低血糖的反调节反应的影响
7. Effects of Antecedent GABAA Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans [O] . Hedrington, Maka S., Farmerie, Stephnie, Ertl, Andrew C., 2010

机译：先前的GABAA激活与阿普唑仑对健康人对低血糖的反调节反应的影响

Glucokinase Activators AZD6370 and AZD1656 Do Not Affect the Central Counterregulatory Response to Hypoglycemia in Healthy Males

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