Intranuclear Inclusion Bodies in the Epithelium of the Human Vas Deferens

摘要

Prominent intranuclear inclusion bodies in epithelial cells of the human vas deferens are common. Four different types of such inclusion bodies have been identified by electron microscopic studies in fertile males. Certain types of these inclusion bodies stain positive for PAS. Although the origin and functional significance of these intranuclear inclusion bodies are not very well known, they should not be interpreted as pathologic changes of the vas deferens epithelium. Case Report A 39-year-old Caucasian male sought for sterilization and underwent vasectomy in the hospital. Past medical history was noncontributory.Two segments of excised vas deferens (left and right), measuring approximately 2.0 cm each in length, were grossly normal. Microscopically, both segments showed complete cross-section. The lumens were lined by psedostratified, columnar epithelium. The epithelial cells stained uniformly with hematoxylin and eosin, with the exception of intranuclear inclusion bodies appearing in a certain population of columnar cells. These intranuclear inclusion bodies were spheroidal, homogeneous and devoid of any internal structure. They varied in size from 0.3 μm to 2.0 μm in diameter (Figure 1). Further studies revealed that some of these intranuclear inclusion bodies were positive for Periodic Acid Schiff (PAS) stain (Figure 2). The stromal loose connective tissue beneath the epithelium and the outer muscular wall showed no histopathologic abnormalities.What is your diagnosis?Pathologic Diagnosis: Complete cross-section of bilateral vas deferens, with no significant histopathologic abnormalities.